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Pseudoxanthoma Elasticum-Like Papillary Dermal Elastolysis: Immunohistochemical Study Using Elastic Fiber Cross-Reactivity With an Antibody Against Amyloid P Component.
MedLine Citation:
PMID:  22722462     Owner:  NLM     Status:  Publisher    
ABSTRACT:: Pseudoxanthoma elasticum (PXE)-like papillary dermal elastolysis is a rare disorder clinically characterized by multiple, asymptomatic nonfollicular papules, yellow or flesh colored, grouped to form plaques with cobblestone appearance. These plaques are arranged symmetrically on the neck and supraclavicular areas of adult or elderly women, closely resembling the lesions of PXE. Histopathologically, the lesions are characterized by a band-like area of elastolysis along the papillary dermis. We report 2 cases of PXE-like papillary dermal elastolysis, in which the anomalies of the elastic tissue were immunohistochemically investigated with an antibody to the amyloid P component. This immunostaining demonstrated a band-like loss of elastic tissue along the papillary dermis. No clumping, fragmentation, or calcification of the elastic tissue was seen. We also review the literature about this rare process and discuss the differential diagnosis with other elastic tissue disorders that may show similar clinical and/or histopathologic findings.
Juan M Revelles; Salma Machan; Ursula Pielasinski; Diana Camacho; Lara Vallés; Carlos Santonja; Heinz Kutzner; Luis Requena
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-20
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  -     ISSN:  1533-0311     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of *Dermatology; and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain ‡Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany.
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