| Pseudotumor cerebri during Cushing's disease treatment with ketoconazole. | |
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MedLine Citation:
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PMID: 21779632 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Benign intracranial hypertension (Pseudotumor cerebri) has been described as related to the reduction in steroid levels in Cushing's disease (CD), especially after surgical remission. Ketoconazole is a common and effective adjuvant therapy for hypercortisolism, but the major concern is liver enzyme dysfunction. We describe here the case of a 12-year old girl with CD who developed benign intracranial hypertension during treatment with ketoconazole. She presented headache, vomiting, a black spot on her right temporal visual field, and signs of elevated intracranial pressure. Pituitary image was normal on magnetic resonance image (MRI), and all symptoms improved after treatment with acetazolamide. We call attention to the diagnosis of this disorder in CD patients, especially children on ketoconazole treatment, because it could be confounded with adrenal insufficiency and lead to definitive severe visual impairment. |
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Authors:
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Fabiola Costenaro; Ticiana C Rodrigues; Nelson P Ferreira; Tiago G da Costa; Tiago Schuch; Vitor Boschi; Mauro A Czepielewski |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arquivos brasileiros de endocrinologia e metabologia Volume: 55 ISSN: 1677-9487 ISO Abbreviation: Arq Bras Endocrinol Metabol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403437 Medline TA: Arq Bras Endocrinol Metabol Country: Brazil |
Other Details:
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Languages: eng Pagination: 284-7 Citation Subset: IM |
Affiliation:
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Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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