Document Detail

Pseudoprogression in high-grade glioma.
MedLine Citation:
PMID:  23190289     Owner:  NLM     Status:  In-Data-Review    
Pseudoprogression is a treatment-related effect seen on imaging in high-grade glioma. Enhancement of gadolinium contrast on control MRI can be misinterpreted as tumor recurrence and is also difficult to distinguish from radiation necrosis. Pseudoprogression is seen in up to 30% after standard treatment for glioblastoma multiforme (GBM), which is radiotherapy concurrent with chemotherapy with temozolomide (TMZ) and adjuvant cycles of TMZ. In this article, the current literature on pseudoprogression in high-grade glioma is reviewed by searches in PubMed. We also present two clinical cases, one of which had medullary pseudoprogression. No articles on this subentity of pseudoprogression were found in PubMed. Standard MRI with gadolinium contrast cannot differentiate between pseudoprogression, tumor recurrence and radiation necrosis. More advanced imaging techniques are often not available. Pseudoprogression seems to be related to methylated promoter of the O(6) - methyl-guanine methyl transferase (MGMT) gene, which is associated with improved treatment effect. Discontinuation or change of therapy on the basis of misinterpretation of MRI as disease progression is thus unfortunate. MRI should be interpreted with caution the first 6 months after standard treatment of high-grade glioma. In a GBM patient with contrast enhancement on MRI but few or no new symptoms and/or stable steroid doses, treatment should be continued and control imaging performed after 2-3 months.
K M Knudsen-Baas; G Moen; O Fluge; A Storstein
Related Documents :
19039049 - Usefulness of susceptibility-weighted imaging for voxel placement in mr spectroscopy.
6639939 - Natural abundance carbon-13 nuclear magnetic resonance spectroscopy of liver and adipos...
2701809 - Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney, and cancer. a ...
8805839 - Is ph a biochemical marker of iq?
18666129 - High resolution localized two-dimensional mr spectroscopy in mouse brain in vivo.
15645149 - White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy i...
22082739 - Congenital cardiovascular malformations: noninvasive imaging by mri in neonates.
10604409 - Lymph node detection of head and neck squamous cell carcinomas by positron emission tom...
23096169 - High-resolution ct findings in fibrotic idiopathic interstitial pneumonias with little ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica. Supplementum     Volume:  -     ISSN:  1600-5449     ISO Abbreviation:  Acta Neurol. Scand., Suppl.c     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370337     Medline TA:  Acta Neurol Scand Suppl     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical assessment and management of sleep disorders in multiple sclerosis: a literature review.
Next Document:  Chronic Lyme; diagnostic and therapeutic challenges.