Document Detail

The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.
MedLine Citation:
PMID:  15066027     Owner:  NLM     Status:  MEDLINE    
To cope with iron deficiency fluorescent pseudomonads produce pyoverdines which are complex peptidic siderophores that very efficiently scavenge iron. In addition to pyoverdine some species also produce other siderophores. Recently, it was shown that Pseudomonas fluorescens ATCC 17400 produces the siderophore quinolobactin, an 8-hydroxy-4-methoxy-2-quinoline carboxylic acid (Mossialos, D., Meyer, J.M., Budzikiewicz, H., Wolff, U., Koedam, N., Baysse, C., Anjaiah, V., and Cornelis, P. (2000) Appl Environ Microbiol 66: 487-492). The entire quinolobactin biosynthetic, transport and uptake gene cluster, consisting out of two operons comprising 12 open reading frames, was cloned and sequenced. Based on the genes present and physiological complementation assays a biosynthetic pathway for quinolobactin is proposed. Surprisingly, this pathway turned out to combine genes derived from the eukaryotic tryptophan-xanthurenic acid branch of the kynurenine pathway and from the pathway for the biosynthesis of pyridine-2,6-bis(thiocarboxylic acid) from P. stutzeri, PDTC. These results clearly show the involvement of the tryptophan-kynurenine-xanthurenic acid pathway in the synthesis of an authentic quinoline siderophore.
Sandra Matthijs; Christine Baysse; Nico Koedam; Kourosh Abbaspour Tehrani; Lieve Verheyden; Herbert Budzikiewicz; Mathias Schäfer; Bart Hoorelbeke; Jean-Marie Meyer; Henri De Greve; Pierre Cornelis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular microbiology     Volume:  52     ISSN:  0950-382X     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-84     Citation Subset:  IM    
Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Building E, Pleinlaan 2, 1050 Brussels, Belgium.
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MeSH Terms
Cloning, Molecular
DNA Transposable Elements
Gene Expression Regulation, Bacterial
Genes, Bacterial
Iron / metabolism*
Iron Chelating Agents / metabolism,  pharmacology
Kynurenine / metabolism
Molecular Sequence Data
Mutagenesis, Insertional
Pseudomonas fluorescens / drug effects,  genetics,  growth & development,  metabolism*
Siderophores / biosynthesis*,  chemistry,  isolation & purification,  metabolism
Tryptophan / metabolism
Xanthurenates / metabolism*,  pharmacology
Reg. No./Substance:
0/DNA Transposable Elements; 0/Iron Chelating Agents; 0/Quinolines; 0/Siderophores; 0/Xanthurenates; 0/quinolobactin; 343-65-7/Kynurenine; 59-00-7/xanthurenic acid; 73-22-3/Tryptophan; 7439-89-6/Iron

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