Document Detail


The Pseudomonas phytotoxin coronatine mimics octadecanoid signalling molecules of higher plants.
MedLine Citation:
PMID:  8194607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phytotoxic principle, coronatine, which is present in several pathovars of the plant pathogen, Pseudomonas syringae was shown to be highly active in completely different, jasmonate-selective bioassays. At nanomolar to micromolar concentrations, coronatine induced the accumulation of defense-related secondary metabolites in several plant cell cultures, induced transcript accumulation of the elicitor-responsive gene encoding the berberine bridge enzyme of Eschscholtzia californica, as well as the coiling response of Bryonia dioica tendrils. Biological activity critically depended upon the structure of coronatine, and slight modifications, such as methylation of the carboxyl moiety or reduction of the carbonyl group, rendered the molecules almost inactive. Coronafacic acid, obtained by hydrolysis of coronatine, was also nearly inactive. Coronatine did not elicit the accumulation of endogenous jasmonic acid in the systems analyzed. While coronafacic acid is similar in structure to jasmonic acid, we found coronatine to be a close structural analogue of the cyclic C18-precursor of jasmonic acid, 12-oxo-phytodienoic acid. The phytotoxic symptoms produced by coronatine can now be understood on the basis of the toxin's action as a mimic of the octadecanoid signalling molecules of higher plants.
Authors:
E W Weiler; T M Kutchan; T Gorba; W Brodschelm; U Niesel; F Bublitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  345     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-29     Completed Date:  1994-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM; S    
Affiliation:
Lehrstuhl für Pflanzenphysiologie, Ruhr-Universität, Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry,  pharmacology*
Bacterial Toxins / chemistry,  pharmacology*
Berberine / metabolism
Biological Assay
Cells, Cultured
Cyclopentanes / chemistry
Dose-Response Relationship, Drug
Fatty Acids, Unsaturated / chemistry,  pharmacology*
Indenes / chemistry,  pharmacology*
Oxylipins
Plants / drug effects*,  enzymology,  genetics
Pseudomonas / chemistry*,  pathogenicity
RNA, Messenger / biosynthesis
Signal Transduction*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Bacterial Toxins; 0/Cyclopentanes; 0/Fatty Acids, Unsaturated; 0/Indenes; 0/Oxylipins; 0/RNA, Messenger; 2086-83-1/Berberine; 62251-96-1/coronatine; 67204-66-4/12-oxophytodienoic acid; 6894-38-8/jasmonic acid
Comments/Corrections
Erratum In:
FEBS Lett 1994 Aug 1;349(2):317

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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