| Pseudomonas exotoxin and recombinant immunotoxins derived from it. | |
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MedLine Citation:
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PMID: 8363279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pseudomonas exotoxin (PE) is a bacterial toxin that kills mammalian cells by gaining entry to the cytosol and inactivating protein synthesis. The toxin binds and enters cells via the alpha 2-macroglobulin receptors. Within cells, the toxin is processed in several steps to produce an enzymatically active 37-kDa C-terminal fragment which translocates to the cytosol and ADP-ribosylates elongation factor 2. Because PE is a very potent toxin, derivatives of it have been produced which, when joined to various binding ligands, are capable of killing specific target cells. It is hoped that this strategy will lead to the development of effective therapeutic agents for the treatment of human diseases such as cancer, AIDS, and various immunologic disorders. |
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Authors:
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D Fitzgerald; I Pastan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 685 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-09-24 Completed Date: 1993-09-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 740-5 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADP Ribose Transferases* Animals Bacterial Toxins / pharmacology* Exotoxins / pharmacology* Humans Immunotoxins / pharmacology* Pseudomonas aeruginosa* Recombinant Fusion Proteins / pharmacology* Virulence Factors* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Exotoxins; 0/Immunotoxins; 0/Recombinant Fusion Proteins; 0/Virulence Factors; EC 2.4.2.-/ADP Ribose Transferases; EC 2.4.2.31/toxA protein, Pseudomonas aeruginosa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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