| Pseudomonas diminuta LPS with a new endotoxic lipid A structure. | |
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MedLine Citation:
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PMID: 3827908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid A that contains mainly 2,3-diamino-2,3-dideoxy-D-glucose, phosphate and fatty acids in the molar ratio 2:1:5-6 was found in Pseudomonas diminuta lipopolysaccharide. The lipid A was considered to have a diamino-sugar disaccharide structure that carries a nonglycosidic phosphomonoester group and amide-bound acyloxyacyl and 3-hydroxy fatty acyl groups. The lipopolysaccharide exhibited endotoxic activities including lethal toxicity, pyrogenicity, local Shwartzman activity, body weight-decreasing toxicity and Limulus activity. The free lipid A was also endotoxic. |
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Authors:
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N Kasai; S Arata; J Mashimo; Y Akiyama; C Tanaka; K Egawa; S Tanaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 142 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-04-01 Completed Date: 1987-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 972-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Thin Layer Fatty Acids / analysis Glucosamine / analogs & derivatives, analysis Glucose / analysis Heptoses / analysis Lipid A / isolation & purification* Lipopolysaccharides / isolation & purification*, toxicity Magnetic Resonance Spectroscopy Male Mass Spectrometry Mice Pseudomonas / analysis* Sugar Acids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Heptoses; 0/Lipid A; 0/Lipopolysaccharides; 0/Sugar Acids; 1069-03-0/2-keto-3-deoxyoctonate; 3416-24-8/Glucosamine; 50-99-7/Glucose; 55779-66-3/2,3-diamino-2,3-dideoxyglucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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