Document Detail


Pseudomonas aeruginosa bronchopulmonary infection in patients with AIDS, with emphasis on relapsing infection.
MedLine Citation:
PMID:  9701423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to delineate the clinical and therapeutic characteristics of Pseudomonas aeruginosa bronchopulmonary infection in acquired immunodeficiency syndrome (AIDS) patients. Eighteen AIDS patients had 39 episodes of P. aeruginosa bronchopulmonary infection. Their mean CD4 cell count was 0.012+/-0.011 cells x 10(9) x L(-1) and two episodes (5.1%) occurred in neutropenic patients. Ten patients (55.5%) had 21 outbreaks of pseudomonal infection. Relapses were more frequent in patients with chronic bronchitis (80 versus 0%, p=0.03) and in those who received initial oral antibiotic therapy (100 versus 55.6%, p=0.25). Three patients died, but death was directly related to pseudomonal infection in only one patient. In a case-control study, patients with bronchopulmonary P. aeruginosa infection had a survival comparable to patients in the control group. Immunoglobulin prophylaxis was administered to three patients with relapses, without success. The two patients who had P. aeruginosa eradicated were those who began triple antiretroviral therapy and had a CD4 cell increase >0.150 cells x 10(9) x L(-1). Relapsing Pseudomonas aeruginosa bronchopulmonary infection affects patients with advanced human immunodeficiency virus infection, prior underlying lung disease, chronic bronchitis and initial oral antibiotic therapy. Immune reconstitution through triple antiretroviral therapy succeeded in eradicating Pseudomonas aeruginosa respiratory infection in two patients.
Authors:
P Domingo; A Ferré; M A Baraldès; J Ris; F Sánchez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  12     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  107-12     Citation Subset:  IM; X    
Affiliation:
Dept of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / diagnosis*,  drug therapy,  immunology,  mortality
Adult
Anti-Bacterial Agents
Bronchitis / diagnosis*,  drug therapy,  immunology,  mortality
Bronchopneumonia / diagnosis*,  drug therapy,  immunology,  mortality
CD4 Lymphocyte Count
Disease Progression
Drug Therapy, Combination / therapeutic use
Female
Humans
Male
Neutropenia / diagnosis,  drug therapy,  immunology,  mortality
Pseudomonas Infections / diagnosis*,  drug therapy,  immunology,  mortality
Recurrence
Survival Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

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