Document Detail

Pseudomonas aeruginosa: acute lung injury or ventilator-associated pneumonia?
MedLine Citation:
PMID:  20935618     Owner:  NLM     Status:  MEDLINE    
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative, aerobic, rod-shaped and polar-flagella bacterium with unipolar motility. Furthermore, it is an opportunistic pathogen responsible for ventilator-acquired pneumonia (VAP). VAP due to P. aeruginosa is usually multidrug-resistant and associated with severe infection and increased mortality. The goals of this review are as follows: (I) to present selected recent epidemiological literature characterizing the population at risk of P. aeruginosa pneumonia, (II) to describe some of the virulence factors of P. aeruginosa that are related to infection, and (III) to illustrate clinical outcomes of ventilated patients with large burdens of P. aeruginosa as well as the mechanism by which this bacterium may evade the host immune response.
L Berra; J Sampson; J Wiener-Kronish
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  76     ISSN:  1827-1596     ISO Abbreviation:  Minerva Anestesiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  824-32     Citation Subset:  IM    
Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Cohort Studies
Diagnosis, Differential
Host-Pathogen Interactions
Multicenter Studies as Topic / statistics & numerical data
Opportunistic Infections / diagnosis,  epidemiology,  microbiology
Pneumonia, Bacterial / diagnosis*,  epidemiology
Pneumonia, Ventilator-Associated / diagnosis,  epidemiology,  etiology,  microbiology*
Postoperative Complications / diagnosis,  epidemiology,  microbiology
Pseudomonas Infections / diagnosis*,  epidemiology
Pseudomonas aeruginosa / isolation & purification*,  metabolism,  pathogenicity,  ultrastructure
Thoracic Surgical Procedures
Treatment Outcome
Ventilator-Induced Lung Injury / diagnosis,  epidemiology,  microbiology*
Wounds and Injuries / complications

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