Document Detail

Pseudomembranous colitis associated with antibiotic prophylaxis in orthopaedic surgery.
MedLine Citation:
PMID:  3403605     Owner:  NLM     Status:  MEDLINE    
We report 16 orthopaedic patients who had antibiotic-associated diarrhoea (pseudomembranous colitis) after operation. There was an association with the use of cephradine and with the prolongation of prophylaxis for more than three peri-operative doses. Five cases occurred as a cluster, suggesting that the causative agent, Clostridium difficile, may be infectious in some situations.
S R Cannon; P H Dyson; P J Sanderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  70     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  600-2     Citation Subset:  AIM; IM    
Royal National Orthopaedic Hospital, Stanmore, Middlesex, England.
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MeSH Terms
Aged, 80 and over
Cefuroxime / adverse effects,  therapeutic use
Cephalosporins / adverse effects*
Cephradine / adverse effects*,  therapeutic use
Enterocolitis, Pseudomembranous / etiology*
Middle Aged
Postoperative Complications*
Premedication / adverse effects*
Reg. No./Substance:
0/Cephalosporins; 38821-53-3/Cephradine; 55268-75-2/Cefuroxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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