Document Detail

Pseudomelanosis duodeni in an adolescent male: case report and review of the literature.
MedLine Citation:
PMID:  9050065     Owner:  NLM     Status:  MEDLINE    
Pseudomelanosis duodeni is rarely seen in children. It manifests endoscopically as peppery speckles in the duodenal mucosa. This pigment corresponds principally to accumulation of ferrous sulfide in macrophages within the lamina propria. We report the case of a 16-year-old boy with ectodermal dysplasia who underwent renal transplantation for vesicoureteral reflux and later developed epigastric pain. Endoscopic and pathologic findings in the duodenal mucosa were typical of pseudomelanosis duodeni. A review of the literature reveals shared clinical features among reported adult and pediatric cases, including chronic renal failure, use of antihypertensive medication and oral iron supplementation, and/or presence of gastric hemorrhage.
S Pueblitz; R H Squires; C F Timmons
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association     Volume:  17     ISSN:  1077-1042     ISO Abbreviation:  Pediatr Pathol Lab Med     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-05-12     Completed Date:  1997-05-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9518033     Medline TA:  Pediatr Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
Department of Pathology, Children's Medical Center of Dallas, Texas, USA.
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MeSH Terms
Cytoplasmic Granules / metabolism,  ultrastructure
Duodenal Diseases / metabolism,  pathology*
Intestinal Mucosa / metabolism,  pathology
Macrophages / metabolism
Melanosis / metabolism,  pathology*
Microscopy, Electron
Pigments, Biological / metabolism
Reg. No./Substance:
0/Pigments, Biological
Comment In:
Pediatr Pathol Lab Med. 1997 Nov-Dec;17(6):987-9   [PMID:  9353842 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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