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Pseudomelanocytic nests mimicking atypical melanocytic proliferations: first reported cases in the oral cavity.
MedLine Citation:
PMID:  25240993     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The concept of pseudomelanocytic nests has been recently described in the dermatology literature. To our knowledge, this entity has yet to be published in the oral pathology literature. We report 2 cases with features of pseudomelanocytic nests. In both instances, nests of cells suspicious for melanocytes were observed. Interpretation of melan-A was negative. Both cases showed strong and diffuse immunoreactivity of the nested cells to CD68. This immunohistochemical staining pattern is most consistent with a melanophage identity. Pseudomelanocytic nests are a recently described entity that represents a potential diagnostic pitfall. Distinguishing pseudomelanocytic nests from an authentic atypical melanocytic proliferation can be challenging and is important for appropriate patient management. Clinicopathologic correlation with cautious interpretation of immunohistochemistry may be necessary to arrive at the correct diagnosis. These cases represent the first reports of pseudomelanocytic nests in the oral pathology literature.
Authors:
Audrey L Boros; Janice P Handlers; Raymond J Melrose
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Publication Detail:
Type:  Journal Article     Date:  2014-06-14
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  118     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-8     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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