Document Detail

Pseudolinkage of the duplicate loci for supernatant aspartate aminotransferase in brook trout, Salvelinus fontinalis.
MedLine Citation:
PMID:  6774006     Owner:  NLM     Status:  MEDLINE    
Electrophoretic variation involving three alleles is described for the duplicated loci for supernatant aspartate aminotransferase (AAT-1,2), from muscle extracts of brook trout. Both loci exhibit largely disomic inheritance. Exceptional progeny types are proposed to be the result of a form of tetrasomic inheritance. Nonrandom segregation was found among the progeny of males doubly heterozygous for AAT markers; where so-called linkage phase was known, this nonrandom assortment was shown to be pseudolinkage (78.9 percent recombination). Analyses of joint segregation of triply heterozygous males for the AAT-(1,2) loci and for the single alpha glycerophosphate dehydrogenase locus (AGP-1) revealed true linkage of AGP-1 with one AAT locus (mean r = 11 percent), but pseudolinkage with the other AAT locus (r = 74 percent). Intraindividual variation for homoeologous multivalent pairing of two acrocentric with two metacentric chromosomes in males, but with bivalent pairing in females, is proposed to account for pseudolinkage and for the tetrasomically inherited types.
J E Wright; B May; M Stoneking; G M Lee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of heredity     Volume:  71     ISSN:  0022-1503     ISO Abbreviation:  J. Hered.     Publication Date:    1980 Jul-Aug
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375373     Medline TA:  J Hered     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
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MeSH Terms
Aspartate Aminotransferases / genetics*
Crosses, Genetic
DNA Replication*
Glycerolphosphate Dehydrogenase / genetics
Linkage (Genetics)
Salmonidae / genetics*
Trout / genetics*
Reg. No./Substance:
EC 1.1.-/Glycerolphosphate Dehydrogenase; EC Aminotransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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