Document Detail


Pseudoephedrine ingestion and cycling time-trial performance.
MedLine Citation:
PMID:  20479486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the current study was to investigate the effect of 180 mg of pseudoephedrine (PSE) on cycling time-trial (TT) performance. Six well-trained male cyclists and triathletes (age 33 +/- 2 yr, mass 81 +/- 8 kg, height 182.0 +/- 6.7 cm, VO2max 56.8 +/- 6.8 ml x kg(-1) x min(-1); M +/- SD) underwent 2 performance trials in which they completed a 25-min variable-intensity (50-90% maximal aerobic power) warm-up, followed by a cycling TT in which they completed a fixed amount of work (7 kJ/kg body mass) in the shortest possible time. Sixty minutes before the start of exercise, they orally ingested 180 mg of PSE or a cornstarch placebo (PLA) in a randomized, crossover, double-blind manner. Venous blood was sampled immediately pre- and postexercise for the analysis of pH plus lactate, glucose, and norepinephrine (NE). PSE improved cycling TT performance by 5.1% (95% CI 0-10%) compared with PLA (28:58.9 +/- 4:26.5 and 30:31.7 +/- 4:36.7 min, respectively). There was a significant Treatment x Time interaction (p = .04) for NE, with NE increasing during the PSE trial only. Similarly, blood glucose also showed a trend (p = .06) for increased levels postexercise in the PSE trial. The ingestion of 180 mg of PSE 60 min before the onset of high-intensity exercise improved cycling TT performance in well-trained athletes. It is possible that changes in metabolism or an increase in central nervous system stimulation is responsible for the observed ergogenic effect of PSE.
Authors:
Kellie R Pritchard-Peschek; David G Jenkins; Mark A Osborne; Gary J Slater
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  20     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
Affiliation:
University of Queensland, Brisbane, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Athletic Performance / physiology*
Bicycling / physiology*
Blood Glucose / metabolism
Central Nervous System Stimulants / blood,  pharmacology*
Cross-Over Studies
Double-Blind Method
Humans
Lactates / blood
Male
Oxygen Consumption / drug effects*
Pseudoephedrine / blood,  pharmacology*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Central Nervous System Stimulants; 0/Lactates; 90-82-4/Pseudoephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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