| Pseudoephedrine ingestion and cycling time-trial performance. | |
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MedLine Citation:
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PMID: 20479486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the current study was to investigate the effect of 180 mg of pseudoephedrine (PSE) on cycling time-trial (TT) performance. Six well-trained male cyclists and triathletes (age 33 +/- 2 yr, mass 81 +/- 8 kg, height 182.0 +/- 6.7 cm, VO2max 56.8 +/- 6.8 ml x kg(-1) x min(-1); M +/- SD) underwent 2 performance trials in which they completed a 25-min variable-intensity (50-90% maximal aerobic power) warm-up, followed by a cycling TT in which they completed a fixed amount of work (7 kJ/kg body mass) in the shortest possible time. Sixty minutes before the start of exercise, they orally ingested 180 mg of PSE or a cornstarch placebo (PLA) in a randomized, crossover, double-blind manner. Venous blood was sampled immediately pre- and postexercise for the analysis of pH plus lactate, glucose, and norepinephrine (NE). PSE improved cycling TT performance by 5.1% (95% CI 0-10%) compared with PLA (28:58.9 +/- 4:26.5 and 30:31.7 +/- 4:36.7 min, respectively). There was a significant Treatment x Time interaction (p = .04) for NE, with NE increasing during the PSE trial only. Similarly, blood glucose also showed a trend (p = .06) for increased levels postexercise in the PSE trial. The ingestion of 180 mg of PSE 60 min before the onset of high-intensity exercise improved cycling TT performance in well-trained athletes. It is possible that changes in metabolism or an increase in central nervous system stimulation is responsible for the observed ergogenic effect of PSE. |
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Authors:
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Kellie R Pritchard-Peschek; David G Jenkins; Mark A Osborne; Gary J Slater |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of sport nutrition and exercise metabolism Volume: 20 ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
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Languages: eng Pagination: 132-8 Citation Subset: IM |
Affiliation:
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University of Queensland, Brisbane, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Athletic Performance / physiology* Bicycling / physiology* Blood Glucose / metabolism Central Nervous System Stimulants / blood, pharmacology* Cross-Over Studies Double-Blind Method Humans Lactates / blood Male Oxygen Consumption / drug effects* Pseudoephedrine / blood, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Central Nervous System Stimulants; 0/Lactates; 90-82-4/Pseudoephedrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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