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Pseudoephedrine and Preexercise Feeding: Influence on Performance.
MedLine Citation:
PMID:  23274597     Owner:  NLM     Status:  Publisher    
PURPOSE: This study examined the influence of pre-exercise food intake on plasma PSE concentrations and subsequent high intensity exercise. Additionally, urinary PSE concentrations were measured under the same conditions and compared to the present WADA threshold. METHODS: Ten highly trained male cyclists and triathletes (age 30.6 ± 6.6 years, body mass 72.9 ± 5.1 kg, O2max 64.8 ± 4.5 ml·kgmin) undertook four cycling time trials (TTs) each requiring the completion of a set amount of work (7 kJ·kg BM) in the shortest possible time. Participants were randomized into a fed or non-fed condition and orally ingested 2.8 mg·kg BM of PSE or a placebo (PLA) 90 min before exercise; in the fed trials, they consumed a meal providing 1.5 g·kg BM of carbohydrate. Venous blood was sampled at 30, 50, 70 min and pre-warm up and post-exercise for the analysis of plasma PSE and catecholamine concentrations, urine was also collected for the analysis of PSE concentration. RESULTS: Independent of the pre-exercise meal, 2.8 mg·kg BM of PSE did not significantly improve cycling TT performance. The fed trials resulted in lower plasma PSE concentrations at all time points compared to the non-fed trials. Both plasma epinephrine and blood lactate concentrations were higher in the PSE compared to the placebo trials and pre- and post-exercise urinary PSE concentrations were significantly higher than the threshold (150 μg·mL) used by WADA to determine illicit PSE use. CONCLUSIONS: Irrespective of the pre-exercise meal, cycling TT performance of ~30 min was not improved following PSE supplementation. Furthermore, 2.8 mg·kg BM of PSE taken 90 min before exercise, with or without food, resulted in urinary PSE concentrations exceeding the present WADA threshold.
Kellie R Pritchard-Peschek; Mark A Osborne; Gary J Slater; Dennis R Taaffe; David G Jenkins
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-27
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia 2Athlete and Coach Support Services, Queensland Academy of Sport, Brisbane, Queensland, Australia 3The School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, Queensland, Australia 4School of Environmental and Life Sciences, The University of Newcastle, Ourimbah, New South Wales, Australia.
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