| Pseudocontinuous arterial spin labeling reveals dissociable effects of morphine and alcohol on regional cerebral blood flow. | |
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MedLine Citation:
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PMID: 21245872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined sensitivity and specificity of pseudocontinuous arterial spin labeling (PCASL) to detect global and regional changes in cerebral blood flow (CBF) in response to two different psychoactive drugs. We tested alcohol and morphine in a placebo-controlled, double-blind randomized study in 12 healthy young men. Drugs were administered intravenously. Validated pharmacokinetic protocols achieved minimal intersubject and intrasubject variance in plasma drug concentration. Permutation-based statistical testing of a mixed effect repeated measures model revealed a widespread increase in absolute CBF because of both morphine and alcohol. Conjunction analysis revealed overlapping effects of morphine and alcohol on absolute CBF in the left anterior cingulate, right hippocampus, right insula, and left primary sensorimotor areas. Effects of morphine and alcohol on relative CBF (obtained from z-normalization of absolute CBF maps) were significantly different in the left putamen, left frontoparietal network, cerebellum, and the brainstem. Corroborating previous PET results, our findings suggest that PCASL is a promising tool for central nervous system drug research. |
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Authors:
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Najmeh Khalili-Mahani; Matthias J P van Osch; Evelinda Baerends; Roelof P Soeter; Marieke de Kam; Remco W M Zoethout; Albert Dahan; Mark A van Buchem; Joop M A van Gerven; Serge A R B Rombouts |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-01-19 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-06-28 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1321-33 Citation Subset: IM |
Affiliation:
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Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands. n.mahani@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain Mapping / methods* Central Nervous System Depressants / pharmacology* Cerebrovascular Circulation / drug effects* Double-Blind Method Ethanol / pharmacology* Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging / methods Male Morphine / pharmacology* Narcotics / pharmacology Sensitivity and Specificity Spin Labels Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Narcotics; 0/Spin Labels; 57-27-2/Morphine; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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