Document Detail

Pseudochylothorax without pleural thickening: time to reconsider pathogenesis?
MedLine Citation:
PMID:  19809057     Owner:  NLM     Status:  MEDLINE    
Pseudochylothorax (cholesterol pleurisy or chyliform effusion) is a cholesterol-rich pleural effusion that is commonly associated with chronic inflammatory disorders such as tuberculosis or rheumatoid arthritis. Until now, there were only 15 published cases of arthritis-associated pseudochylothorax in the English language literature. Previous literature has suggested that pleural fluid cholesterol enrichment occurs in the context of grossly thickened (fibrotic) pleura over a prolonged period, usually > 5 years. We present six well-characterized cases of arthritis-associated pseudochylothorax, each notable due to their minimal pleural thickening. The median duration of symptoms (or arthritis, in the case of asymptomatic effusions) was 15 months. Such findings cast significant doubt on the conventional concepts of the pathogenesis of rheumatoid-associated pseudochylothorax. Clinicians should consider pseudochylothorax even in short-duration nonfibrotic pleural effusions.
John M Wrightson; Andrew E Stanton; Nicholas A Maskell; Robert J O Davies; Y C Gary Lee
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  136     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-11-17     Revised Date:  2010-10-12    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1144-7     Citation Subset:  AIM; IM    
Oxford Pleural Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK.
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MeSH Terms
Arthritis, Rheumatoid / complications
Cholesterol / analysis*
Chylothorax / etiology
Middle Aged
Pleural Effusion / etiology*
Pleurisy / etiology
Grant Support
//Medical Research Council
Reg. No./Substance:
Comment In:
Chest. 2010 Oct;138(4):1023; author reply 1023-4   [PMID:  20923810 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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