| Pseudocholinesterase hyperactivity with succinylcholine resistance: an unusual cause of difficult intubation. | |
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MedLine Citation:
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PMID: 9195358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of difficult intubation, possibly due to marked pseudocholinesterase hyperactivity that caused rapid inactivation of succinycholine. Possible causes of difficult intubation and pseudocholinesterase hyperactivity are discussed. Literature on genetic variants associated with markedly increased pseudocholinesterase activity are reviewed. It is concluded that pseudocholinesterase hyperactivity may be a rare cause of difficult intubation. We recommend that pseudocholinesterase activity should be determined in all patients who appear to be resistant to the action of normal doses of succinylcholine or mivacurium. |
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Authors:
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F S Yao; J J Savarese |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical anesthesia Volume: 9 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-01 Completed Date: 1997-08-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 328-30 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, New York Hospital-Cornell University Medical College, NY 10021, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dilatation and Curettage Drug Resistance Female Humans Intubation, Intratracheal* Neuromuscular Depolarizing Agents* Pregnancy Pregnancy, Ectopic / surgery Pseudocholinesterase / blood* Succinylcholine* |
| Chemical | |
Reg. No./Substance:
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0/Neuromuscular Depolarizing Agents; 306-40-1/Succinylcholine; EC 3.1.1.-/Pseudocholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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