Document Detail


Pseudocholinesterase deficiency: a comprehensive review of genetic, acquired, and drug influences.
MedLine Citation:
PMID:  20879632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pseudocholinesterase deficiency is an inherited or acquired condition in which the metabolism of succinylcholine, mivacurium, or ester local anesthetics is potentially impaired. In this review, genetic inheritance, variants, and testing are examined. Additionally, acquired conditions and drugs that influence enzyme activity, as well as possible treatments of the condition, are reviewed. The review of the literature was conducted by searching PubMed and Ovid Medline databases, with no limitation on date of publication. The search was limited to English-language journals only. Additional articles of relevance were obtained from reference lists of previously searched articles and via Internet searches. Numerous keywords were used in the search, and a second search was undertaken to find specific citations about acquired conditions and drugs of relevance. Nearly 250 articles were obtained and examined for importance. Fifty articles appear in the review, including case reports, research studies, and review articles.
Authors:
Flanna K Soliday; Yvette P Conley; Richard Henker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AANA journal     Volume:  78     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  N    
Affiliation:
University of Pittsburgh, Nurse Anesthesia Program, Pennsylvania, USA. jifter@comcast.net
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MeSH Terms
Descriptor/Qualifier:
Anesthetics / pharmacokinetics*
Butyrylcholinesterase / deficiency,  genetics,  metabolism
Genetic Variation
Humans
Nurse Anesthetists*
Pseudocholinesterase / deficiency*,  genetics*,  metabolism
Chemical
Reg. No./Substance:
0/Anesthetics; EC 3.1.1.-/Butyrylcholinesterase; EC 3.1.1.-/Pseudocholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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