Document Detail

Pseudo-exfoliation fibrils examined by negative staining.
MedLine Citation:
PMID:  78658     Owner:  NLM     Status:  MEDLINE    
Pseudo-exfoliation (PE) material, collected from lenses extracted because of cataract, has been examined by negative staining. The material was fragmented by ultrasound into single fibrils and small collections of fibrils. The fibrils were composed of a small number of filamentous subunits associated with or surrounded by a fuzzy material which had side excrescences at regular intervals of 50--55 nm or 25--30 nm. The side excrescences correspond to the cross-bands of the PE fibrils. It is proposed that the PE fibrils are composed of a few subunits of a fibrillar protein, which form a core to which glycosaminoglycan side chains are attached. The visible periodicity of the PE fibrils, appearing as cross-bands, is thought to be caused by clusters of glycosaminoglycan distributed at regular intervals along the fibrils.
M Davanger; T Hovig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  56     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
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MeSH Terms
Cytoskeleton / ultrastructure
Lens Diseases / pathology*
Lens, Crystalline / ultrastructure*
Microscopy, Electron
Staining and Labeling*

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