Document Detail

Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones.
MedLine Citation:
PMID:  16632273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton. STUDY DESIGN: The histology and immunohistochemistry of 4 PSOFs, 6 COFs, and 7 PMs was studied. Antibodies included EMA, cytokeratins, smooth muscle actin (SMA), desmin, vimentin, CD34, CD10, S-100 protein, and glial fibrillary acidic protein (GFAP). RESULTS: All PSOFs showed multiple round ossicles homogeneously distributed within a fibroblastic stroma. Psammomatous meningiomas had meningothelial features. All tumors, except 1 COF, were positive for EMA. All of them expressed vimentin, and none showed cytokeratins. Staining for SMA and S-100 protein was variable. CD10 was positive in all cases except 2 meningiomas. CD34 and GFAP stained only 1 case of meningioma each. CONCLUSIONS: The diagnosis of PSOF should rest on histologic features. An incorrect diagnosis of meningioma based on the expression of EMA should be avoided.
Rosario Granados; Rosario Carrillo; Laura Nájera; Mercedes García-Villanueva; Mercedes Patrón
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Publication Detail:
Type:  Journal Article     Date:  2006-02-17
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  101     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-05-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-9     Citation Subset:  D; IM    
University Hospital of Getafe, Madrid, Spain.
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MeSH Terms
Actins / analysis
Antigens, CD34 / analysis
Bone Neoplasms / chemistry,  pathology*
Cementoma / chemistry,  diagnosis
Diagnosis, Differential
Ethmoid Sinus / pathology*
Fibroma, Ossifying / chemistry,  pathology*
Immunoenzyme Techniques
Jaw Neoplasms / chemistry,  diagnosis
Meningeal Neoplasms / chemistry,  diagnosis
Meningioma / chemistry,  diagnosis
Middle Aged
Mucin-1 / analysis
Paranasal Sinus Neoplasms / chemistry,  pathology*
Sphenoid Sinus / pathology*
Vimentin / analysis
Reg. No./Substance:
0/Actins; 0/Antigens, CD34; 0/Mucin-1; 0/Vimentin

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