| Prurigo nodularis. Histological and electron microscopical study. | |
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MedLine Citation:
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PMID: 1200655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a typical case of prurigo nodularis, of 15 years' duration, in a middle-aged woman. Histological and electron microscopical examination of the skin lesions revealed distinct changes in the nerve tissue. There were groups of thickened nerve fibers that formed nodules with numerous Schwann cells. Some of the nerve bundles extended to the dermoepidermal junction. Electron microscopy showed very obvious lesions in the Schwann cells and axons. In the Schwann cells there was a lucent cytoplasm with few mitochondria, an absence of endoplasmic reticulum and a few irregular, membrane-bound vacuoles. While the mesaxons all appeared normal, the axons varied greatly in diameter; the small ones appeared normal and contained neurofibrils and neurotubules, whereas the large onew were empty. Every Schwann cell encircled a large number of axons. It may be assumed that the axon swelling is a nonspecific reaction to injury. |
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Authors:
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E J Feuerman; M Sandbank |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 111 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1975 Nov |
Date Detail:
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Created Date: 1976-02-09 Completed Date: 1976-02-09 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1472-7 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Prurigo / pathology* Sex Factors Skin / pathology*, ultrastructure Stress, Psychological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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