Document Detail

Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger.
MedLine Citation:
PMID:  15895530     Owner:  NLM     Status:  MEDLINE    
In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The structure of prunustatin A was determined by a series of NMR analyses to be an oxidized type of the neoantimycin family. Prunustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without showing cytotoxicity under normal nutrient condition.
Yukiko Umeda; Shuhei Chijiwa; Kazuo Furihata; Keiko Furihata; Shohei Sakuda; Hiromichi Nagasawa; Hidenori Watanabe; Kazuo Shin-ya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  58     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-06-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  206-9     Citation Subset:  IM    
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
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MeSH Terms
Cell Line
Chemistry, Physical
Deoxyglucose / pharmacology
Down-Regulation / drug effects
Genes, Reporter
Heat-Shock Proteins / antagonists & inhibitors*,  genetics*
Luciferases / genetics
Macrolides / chemistry,  isolation & purification*,  pharmacology*
Magnetic Resonance Spectroscopy
Molecular Chaperones / antagonists & inhibitors*,  genetics*
Molecular Structure
Physicochemical Phenomena
Promoter Regions, Genetic
Spectrometry, Mass, Fast Atom Bombardment
Streptomyces / chemistry*,  isolation & purification
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Macrolides; 0/Molecular Chaperones; 0/molecular chaperone GRP78; 0/prunustatin A; 154-17-6/Deoxyglucose; EC 1.13.12.-/Luciferases

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