Document Detail

Prunella vulgaris Attenuates Prepulse Inhibition Deficit and Attention Disruption induced by MK-801 in Mice.
MedLine Citation:
PMID:  23348874     Owner:  NLM     Status:  Publisher    
Prunella vulgaris var. lilacina is widely distributed in Korea, Japan, China, and Europe, and it has been traditionally used to treat inflammation or hypertension. In the present study, we investigated the effects of the ethanolic extract of the spikes of Prunella vulgaris var. lilacina (EEPV) on dizocilpine (MK-801)-induced schizophrenia-like phenotype behaviors such as the disruption of prepulse inhibition and attention deficits in mice. We also determined the effect of EEPV on MK-801-induced alterations in phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, phospho-glycogen synthase kinase 3-β, and phosphorylated cAMP response element-binding protein levels in the cortex and hippocampus of mice. MK-801-induced prepulse inhibition deficits were ameliorated by the administration of EEPV, as shown in the acoustic startle response test. Furthermore, EEPV attenuated the MK-801-induced attention deficits in the water finding test. We also found that EEPV attenuated the increased phosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, or phospho-glycogen synthase kinase 3-β levels induced by MK-801 in the cortex but not in the hippocampus. These results suggest that EEPV could be useful for treating schizophrenia because EEPV ameliorates prepulse inhibition disruption and attention deficits induced by MK-801. Copyright © 2013 John Wiley & Sons, Ltd.
Se Jin Park; Se Jin Jeon; Ike C Dela Peña; Hyung Eun Lee; Dong Hyun Kim; Jong Min Kim; Young Woo Lee; Jun Man Jung; Bum Young Shin; Seungheon Lee; Jae Hoon Cheong; Chan Young Shin; Dae Sik Jang; Jong Hoon Ryu
Related Documents :
9593124 - Metabolism in human cells of the d and l enantiomers of the carbocyclic analog of 2'-de...
24236444 - Psk1 regulates expression of sod1 involved in oxidative stress tolerance in yeast.
2549034 - Human deoxycytidine kinase. sequence of cdna clones and analysis of expression in cell ...
24578384 - Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induce...
10230394 - Phosphorylation and inactivation of bad by mitochondria-anchored protein kinase a.
195614 - Influence of dibutyryl cyclic amp on thymidine uptake by herpes simplex virus infected ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  -     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Middle Ear Effusion in Patients with Sinonasal Cancer Treated by Surgery with or without Radiotherap...
Next Document:  Temperature-dependent zero-field splitting in a copper(ii) dimer studied by EPR.