Document Detail

Proximal tubule angiotensinogen modulation of arterial pressure.
MedLine Citation:
PMID:  23010762     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Although the existence of a complete intrarenal renin-angiotensin system is now well established, its role in modulating tubule sodium transport and blood pressure is incompletely understood. Several recent studies have shed light on one component of the system, proximal tubule-derived angiotensinogen (AGT). This review discusses the synthesis, regulation and function of AGT in the proximal tubule.
RECENT FINDINGS: Under normal sodium intake, AGT within the S1 and S2 segments of the proximal tubule may derive from the systemic circulation, whereas the S3 segment synthesizes AGT. Urinary AGT likely primarily reflects proximal tubule-derived AGT. Proximal tubule AGT synthesis is regulated by high Na intake, angiotensin-II and inflammatory cytokines. Transgenic expression of mouse AGT in the proximal tubule causes hypertension. Overexpression of rat AGT in the proximal tubule leads to hypertension, enhanced reactive oxygen species generation via NADPH oxidase, tubular apoptosis and tubulointerstitial fibrosis; these effects can be mitigated by catalase overexpression.
SUMMARY: Proximal tubule-derived AGT has the potential to modulate blood pressure and sodium balance, and promote renal injury. Interactions with the systemic renin-angiotensin system may influence the role of proximal tubule-derived AGT in the kidney.
Nirupama Ramkumar; Donald E Kohan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  22     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-06-03     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
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MeSH Terms
Angiotensinogen / metabolism*,  urine
Blood Pressure
Hypertension / metabolism*
Kidney Tubules, Proximal / metabolism*
Sodium / metabolism
Water / metabolism
Grant Support
Reg. No./Substance:
059QF0KO0R/Water; 11002-13-4/Angiotensinogen; 9NEZ333N27/Sodium

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