Document Detail

Proximal tubular function and hyperfiltration during amino acid infusion in man.
MedLine Citation:
PMID:  3394727     Owner:  NLM     Status:  MEDLINE    
The relations between renal hemodynamics (Inutest, CPAH) and sodium segmental handling (sodium distal delivery, distal reabsorption, and fractional excretion) were studied in 9 healthy adults infused with an isotonic amino acid solution and in 6 subjects infused with 0.9% saline for 3 h at 0.2 ml/min/kg. During all tests maximal water diuresis was induced and maintained to effect analysis of sodium segmental transport. Both types of infusion produced a similar expansion of extracellular volume (weight increase, hematocrit fall, suppressed plasma renin activity and plasma aldosterone). The amino acid infusion increased the glomerular filtration rate (GFR) and renal blood flow without modifying the filtration fraction. With saline no hemodynamic modifications were observed. The expansion with saline depressed proximal and distal sodium reabsorption whereas during amino acid infusion sodium distal delivery was unaltered and the significantly increased sodium fractional excretion was sustained only by depressed distal reabsorption. Therefore, in parallel with the GFR increase, closely dependent on renal vasodilatation, the well-known stimulation of sodium cotransport by amino acids is able to antagonize the effects of expansion on the proximal sodium reabsorption. An explanation of glomerular hyperfiltration based on a primary metabolic stimulation of the proximal tubular function is suggested.
A Claris-Appiani; B M Assael; A S Tirelli; G Cavanna; C Corbetta; G Marra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of nephrology     Volume:  8     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-08-19     Completed Date:  1988-08-19     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Clinica Pediatrica II, Università di Milano, Italia.
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MeSH Terms
Amino Acids / administration & dosage,  pharmacology*
Glomerular Filtration Rate*
Infusions, Intravenous
Kidney Tubules, Proximal / physiology*
Renal Circulation*
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Amino Acids; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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