| Proximal small-bowel mucosal villous intraepithelial lymphocytes. | |
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MedLine Citation:
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PMID: 14987222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small-bowel biopsies are routinely obtained from adult patients as a screening tool to evaluate the possibility of gluten sensitivity (GS). Previous morphological criteria of GS including completely flattened villi are usually absent. In the context of screening for GS, an altered distribution density pattern of villous intraepithelial lymphocytes (IELs) is probably the most sensitive morphological feature to suggest the possibility of GS and prompt the initiation of further medical evaluation. Altered villous IEL density distribution is a more sensitive screening feature than villous IEL counts. With increased small-bowel GS screening biopsies, occasional adults without GS with complete villous flattening and numerous villous IELs are encountered. These patients are usually incorrectly diagnosed with GS. However, they do not respond to a gluten-free diet and slowly improve over months. |
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Authors:
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N S Goldstein |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Histopathology Volume: 44 ISSN: 0309-0167 ISO Abbreviation: Histopathology Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-27 Completed Date: 2004-10-27 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 199-205 Citation Subset: IM |
Affiliation:
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Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA. ngoldstein@beaumont.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Celiac Disease / diagnosis*, immunology Epithelial Cells / ultrastructure Epithelium / immunology*, pathology, surgery Humans Intestinal Mucosa / immunology*, pathology, surgery Intestine, Small / immunology*, pathology, surgery Lymphocytes / immunology* Mass Screening Microvilli / immunology, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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