Document Detail


Proximal signaling molecules as potential targets for anti-inflammatory therapy.
MedLine Citation:
PMID:  17786854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As a consequence of the limited efficacy and significant toxicity of current anti-inflammatory therapies, there is widespread interest in the development of novel drugs for this application. Progress in our understanding of inflammatory signaling pathways has identified novel targets, notably in pathways involving mitogen-activated protein kinases and T-cell receptor signaling. Recent observations have provided molecular insight into the mechanism of action of well-established anti-inflammatory and immunosuppressive drugs, such as glucocorticoids and azathioprine, and the anti-inflammatory small molecule semapimod (Cytokine PharmaSciences Inc). Data from these studies indicate that therapeutic agents which specifically target proximal signaling molecules might represent a powerful strategy for combating inflammatory diseases.
Authors:
Mark Löwenberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in drug discovery & development     Volume:  10     ISSN:  1367-6733     ISO Abbreviation:  Curr Opin Drug Discov Devel     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100887519     Medline TA:  Curr Opin Drug Discov Devel     Country:  England    
Other Details:
Languages:  eng     Pagination:  560-4     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands. m.lowenberg@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Drug Design*
Humans
Inflammation / drug therapy*,  immunology,  metabolism
Proto-Oncogene Proteins c-raf / metabolism
Receptors, Antigen, T-Cell / metabolism*
Signal Transduction / drug effects*,  immunology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Receptors, Antigen, T-Cell; EC 2.7.11.1/Proto-Oncogene Proteins c-raf

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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