| Proximal colonic propagating pressure waves sequences and their relationship with movements of content in the proximal human colon. | |
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MedLine Citation:
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PMID: 18194155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormal colonic motor patterns have been implicated in the pathogenesis of severe constipation. Yet in health, the mechanical link between movement of colonic content and regional pressures have only been partially defined. This is largely due to current methodological limitations. Utilizing a combination of simultaneous colonic manometry, high-resolution scintigraphy and a quantitative technique for detecting discrete episodic flow, our aim was to examine the propulsive properties of colonic propagating sequences (PS) in the healthy colon. In six healthy volunteers a nasocolonic manometry catheter was positioned to record colonic pressures at 7.5 cm intervals from terminal ileum to the splenic flexure. With subjects positioned under a gamma camera, 30 MBq of (99m)Tc sulfur colloid was instilled into the terminal ileum, 22.5 cm proximal to the ileocolonic junction. Isotopic images were recorded (10 s/frame) and synchronized with the manometric trace. In the proximal colon we identified 137 antegrade PSs, of which 93% were deemed to be associated temporally with movements of luminal content. Low amplitude PSs, with component pressure waves between 2 mmHg and 5 mmHg, were as likely to be associated with colonic movements as higher amplitude PSs. As such there was no correlation between the amplitude of the PS and the temporal relationship with colonic movements. Within the proximal colon, 24 retrograde PSs were identified, 23 of which were associated with retrograde movements of colonic content. We conclude that proximal colonic PSs are highly propulsive and are a major determinant of proximal colonic flow. |
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Authors:
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P G Dinning; M M Szczesniak; I J Cook |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-13 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 20 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 512-20 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, The St. George Hospital, University of New South Wales, Sydney, Australia. P.dinning@unsw.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colon / physiology* Gastrointestinal Transit / physiology* Humans Male Manometry / methods Peristalsis / physiology* Pressure Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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