Document Detail

Proximal and overall gastric emptying of solids in patients with reduced gastric volume accommodation compared to matched controls.
MedLine Citation:
PMID:  21327917     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interventions such as gastric surgery and erythromycin result in displacement of solids to the distal stomach and acceleration of overall and proximal gastric emptying. The effect of non-surgical impairment of gastric accommodation on gastric emptying is unclear. Non-surgical impairment of gastric accommodation is associated with accelerated gastric emptying.
AIM: To compare measurements of proximal and overall gastric emptying in patients with reduced postprandial gastric volume accommodation with the emptying rates in age- and gender-matched controls with normal postprandial gastric volume accommodation.
METHODS: We evaluated overall and proximal gastric emptying in nine patients with impaired gastric accommodation and age-equivalent and gender-matched controls. Gastric volumes and emptying were measured using validated SPECT and dual gamma camera scintigraphy, respectively. We compared group differences in overall and proximal gastric emptying t (1/2) by t test.
RESULTS: Patients with impaired postprandial gastric volume accommodation had greater fasting gastric volume. The proportion of food emptied from the proximal stomach immediately after meal ingestion was lower and t (1/2) of proximal gastric emptying correspondingly longer in the group with reduced postprandial gastric accommodation. In contrast, differences were not detected in overall gastric emptying in the two groups, and the ratio of overall to proximal gastric emptying t (1/2) was greater in the group with impaired volume accommodation.
CONCLUSIONS: Proximal stomach emptying is reduced in patients with impaired postprandial volume accommodation; this difference occurs predominantly during the time of meal ingestion. Compensatory mechanisms that result in normal overall gastric emptying require further elucidation.
Michael Camilleri; Mary Breen; Michael Ryks; Duane Burton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-17
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  56     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-19     Completed Date:  2011-07-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1729-34     Citation Subset:  AIM; IM    
Mayo Clinic College of Medicine, Charlton 8-110, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Fundoplication / adverse effects
Gastric Balloon / adverse effects
Gastric Emptying / physiology*
Middle Aged
Postprandial Period
Stomach / surgery
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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