Document Detail

Proximal Crohn's disease: review of the clinicopathologic features and therapy.
MedLine Citation:
PMID:  11720325     Owner:  NLM     Status:  MEDLINE    
Crohn's disease in the proximal region of the digestive tract is uncommon. Better diagnostically procedures and more careful histologic examination has led to a higher detection of proximal Crohn's disease. The diagnosis is based on symptoms, endoscopy with serial sections, or double contrast radiography. The most common histologic finding for this diagnosis are granulomas in the mucosa in Helicobacter pylori-negative patients, but the granulomas are not always frequently detected. Endoscopic lesions in the proximal regions look like the lesions that could be found in the distal regions. Notching in the duodenal folds could be a strong indication for Crohn's desease. Radiological lesions are not always characteristic, but should be used in combination with endoscopy. Stenosis is an important complication, but fistula formation and pseudodiverticular formation is possible. There is no uniform medical therapy, but the regular anti-inflammatory management for Crohn's disease is most often used. Sometimes surgery is needed.
R A van Hogezand; A M Witte; R A Veenendaal; M J Wagtmans; C B Lamers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  7     ISSN:  1078-0998     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-26     Completed Date:  2002-03-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-37     Citation Subset:  IM    
Department of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
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MeSH Terms
Crohn Disease / diagnosis*,  pathology,  therapy*
Diagnosis, Differential
Duodenum / pathology
Esophagus / pathology
Jejunum / pathology
Stomach / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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