Document Detail

Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells.
MedLine Citation:
PMID:  16122728     Owner:  NLM     Status:  MEDLINE    
The development of the mammalian pancreas is governed by various signaling processes and by a cascade of gene activation events controlled by different transcription factors. Here we show that the divergent homeodomain transcription factor Prox1 is a novel, crucial regulator of mouse pancreas organogenesis. Loss of Prox1 function severely disrupted epithelial pancreas morphology and hindered pancreatic growth without affecting significantly the genesis of endocrine cells before E11.5. Conversely, the lack of Prox1 activity substantially decreased the formation of islet cell precursors after E13.5, during a period known as the "secondary transition". Notably, this defect occurred concurrently with an abnormal increment of exocrine cells. Hence, it is possible that Prox1 contributes to the allocation of an adequate supply of islet cells throughout pancreas ontogeny by preventing exocrine cell differentiation of multipotent pancreatic progenitors. Prox1 thus appears to be an essential component of a genetic program destined to produce the cellular complexity of the mammalian pancreas.
Junfeng Wang; Gamze Kilic; Muge Aydin; Zoe Burke; Guillermo Oliver; Beatriz Sosa-Pineda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  286     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-12-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-94     Citation Subset:  IM    
Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA.
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MeSH Terms
Base Sequence
Cell Cycle
Cell Differentiation
DNA, Complementary / genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gestational Age
Homeodomain Proteins / genetics,  physiology*
Islets of Langerhans / cytology,  embryology*
Mice, Knockout
Multipotent Stem Cells / cytology
Oligonucleotide Array Sequence Analysis
Pancreas / cytology,  embryology*
Signal Transduction
Transcription Factors / genetics,  physiology*
Transcriptional Activation
Tumor Suppressor Proteins
Grant Support
Reg. No./Substance:
0/DNA, Complementary; 0/Homeodomain Proteins; 0/Transcription Factors; 0/Tumor Suppressor Proteins; 0/prospero-related homeobox 1 protein

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