Document Detail


Provoking allergens and treatment of anaphylaxis in children and adolescents - data from the anaphylaxis registry of German-speaking countries.
MedLine Citation:
PMID:  21435004     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To cite this article: Hompes S, Köhli A, Nemat K, Scherer K, Lange L, Rueff F, Rietschel E, Reese T, Szepfalusi Z, Schwerk N, Beyer K, Hawranek T, Niggemann B, Worm M. Provoking allergens and treatment of anaphylaxis in children and adolescents - data from the anaphylaxis registry of German-speaking countries. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399-3038.2011.01154.x. ABSTRACT: Anaphylaxis is the most severe reaction of an IgE-mediated hypersensitivity. Data about affected patients may help to improve our knowledge of anaphylaxis and its medical care. We analysed data from the anaphylaxis registry of German speaking countries with regard to the provoking allergens and treatment modalities of anaphylaxis in children and adolescents. Inclusion criteria were severe systemic allergic reactions with concomitant pulmonary and/or cardiovascular symptoms. The data are collected by a password-controlled online-questionnaire. For this analysis, data of 197 reported anaphylactic reactions from children and adolescents registered between 2006 and 2009 were included. The data show that within the registered cases the most frequently affected organ systems for children and adolescents were the skin (89%) and the respiratory tract (87%) followed by symptoms of the cardiovascular system (47%) and the gastrointestinal tract (43%). The most frequent elicitors were food allergens accounting for 58% of cases, followed by insect venom (24%) and drugs (8%). The most frequent food allergens were peanuts followed by tree nuts and animal related food products. In 18% aggravating factors such as physical exercise were noted by the clinicians. 26% of the analysed patients had experienced more than one reaction. The data regarding the emergency treatment show that antihistamines (87%) and corticosteroids (85%) were often used but that adrenaline was rarely used (22% of the registered cases). Taken together these data show that the analysis of anaphylaxis by registration of affected individuals can provide data about provoking allergens and treatment measures but also suggest the impact of aggravating factors on anaphylactic reactions. The under-represented usage of adrenaline indicates the need of educational measures for patients and their physicians.
Authors:
Stephanie Hompes; Alice Köhli; Katja Nemat; Kathrin Scherer; Lars Lange; Franziska Rueff; Ernst Rietschel; Thomas Reese; Zsolt Szepfalusi; Nicolaus Schwerk; Kirsten Beyer; Thomas Hawranek; Bodo Niggemann; Margitta Worm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-16
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  -     ISSN:  1399-3038     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology and Allergy, University Hospital Charité Berlin, Germany Division of Allergy, Department of Paediatrics, University Children's Hospital Zurich, Switzerland Department of Paediatrics, University Hospital Carl Gustav Carus, Technical University of Dresden, Germany Allergy Unit, Department of Dermatology, University Hospital Basel, Switzerland Children's Hospital, St. Marien-Hospital Bonn, Germany Department of Dermatology and Allergology, Ludwig-Maximilian-University Munich, Germany Children's Hospital, University of Cologne, Germany Children's Hospital, Mathias-Spital Rheine, Germany Department of Paediatrics, Medical University of Vienna, Austria Clinic of Paediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany Department of Paediatric Pneumology and Immunology, University Hospital Charité Berlin, Germany Department of Dermatology, Paracelsus Medical University Salzburg, Austria Paediatric Allergology and Pneumology, German Red Cross Hospital Westend, Berlin, Germany.
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