Document Detail

Provocation of coronary spasm by dopamine in patients with active variant angina pectoris.
MedLine Citation:
PMID:  3731418     Owner:  NLM     Status:  MEDLINE    
The effects of dopamine on arteries are different depending on the dose, route of administration, and receptor population. Its administration can cause vasodilation by stimulation of dopaminergic receptors, vasoconstriction by stimulation of alpha-adrenergic and serotonergic receptors, and even spasm of cerebral arteries when given intracisternally in dogs. The ability of dopamine to provoke coronary spasm was assessed in 18 patients with active vasospastic angina in whom this amine was infused at rates of 5, 10, and 15 micrograms/kg/min for periods of 5 min each. The 12-lead electrocardiogram and blood pressure (cuff) were monitored throughout the whole test. In nine patients dopamine caused angina and ischemic electrocardiographic changes suggestive of coronary spasm: ST segment elevation in six patients and ST segment depression in the absence of important coronary stenoses in the remaining three. Infusion of dopamine was repeated during coronary angiography in three patients with positive test results: this provoked occlusive coronary spasm with ST segment elevation in two patients and nonocclusive spasm with ST segment depression in the remainder. In conclusion, infusion of dopamine provokes coronary spasm in a sizeable proportion of patients with active vasospastic angina. Its administration may be detrimental in patients susceptible to coronary spasm, such as those with acute myocardial infarction.
F Crea; S Chierchia; J C Kaski; G J Davies; A Margonato; D O Miran; A Maseri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  74     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-9     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / diagnosis,  etiology,  physiopathology*
Blood Pressure
Coronary Vasospasm / chemically induced
Dopamine / diagnostic use*
Ergonovine / diagnostic use
Hemodynamics / drug effects
Middle Aged
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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