Document Detail

Provitamin A carotenoid intake and carotid artery plaques: the Atherosclerosis Risk in Communities Study.
MedLine Citation:
PMID:  9734754     Owner:  NLM     Status:  MEDLINE    
We examined the cross-sectional association between intake of carotenoids with provitamin A activity and carotid artery plaques in 12,773 participants of the Atherosclerosis Risk in Communities Study aged 45-64 y. Usual diet was assessed with a 66-item food-frequency questionnaire. Plaques were examined by B-mode ultrasound of multiple carotid artery segments. In both women and men, those in the highest quintile of carotenoid consumption had a lower prevalence of plaques (women, 25.4%; men, 36.0%) than those in the lowest quintile of carotenoid consumption (women, 29.3%; men, 39.8%). The prevalence odds ratios contrasting extreme intake quintiles were 0.82 (95% CI: 0.70, 0.97) in women and 0.85 (95% CI: 0.72, 1.01) in men. The associations diminished slightly after potential confounders were adjusted for. In women, the inverse association was particularly strong for current smokers (adjusted odds ratio contrasting extreme quintiles: 0.67; 95% CI: 0.45, 0.98). In men, no such effect modification by smoking was seen. The inverse association was somewhat stronger in men aged 55-64 y than in those aged 45-54 y, whereas age made little difference in women. These findings, together with previous findings that carotenoid intake was unrelated to average carotid artery wall thickness, suggest that carotenoids may exert their influence later rather than earlier in the atherosclerotic process, and support the hypothesis that carotenoids or other plant-derived compounds may play a role in preventing arterial plaque formation.
S B Kritchevsky; G S Tell; T Shimakawa; B Dennis; R Li; L Kohlmeier; E Steere; G Heiss
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  68     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-29     Completed Date:  1998-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  726-33     Citation Subset:  AIM; IM    
Department of Preventive Medicine, University of Tennessee, Memphis 38105, USA.
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MeSH Terms
Arteriosclerosis / epidemiology,  prevention & control*,  ultrasonography
Carotenoids / administration & dosage*,  therapeutic use
Carotid Arteries / pathology*,  ultrasonography
Cross-Sectional Studies
Diet Surveys
Middle Aged
Prospective Studies
Risk Factors
Smoking / adverse effects*
United States / epidemiology
Grant Support
Reg. No./Substance:
Comment In:
Am J Clin Nutr. 1998 Sep;68(3):521-2   [PMID:  9734724 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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