Document Detail


Provisional QTL for circadian period of wheel running in laboratory mice: quantitative genetics of period in RI mice.
MedLine Citation:
PMID:  10373097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wheel running was monitored in B x D recombinant inbred (RI) mice under dark-dark (DD) conditions, and the mean circadian period was calculated for each strain. There were significant differences for this trait among B x D recombinant inbred strains (p < .0001) and a narrow-sense heritability of 21%. Analysis of strain means and variances indicates that at least four segregating loci contribute to the genetic variance for the free-running circadian period in this population. Correlation of the strain means for the circadian period of wheel running for each RI strain against the distribution of markers at over 1500 loci along the mouse genome identified a number of provisional quantitative trait loci (QTL). There were provisional QTL for wheel running at p < .001 on chromosome 11 and at p < .01 on chromosomes 1, 6, 9, 17, and 19. Most were in agreement with a second analysis done under similar conditions.
Authors:
J R Hofstetter; B Possidente; A R Mayeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chronobiology international     Volume:  16     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-23     Completed Date:  1999-07-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-79     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Richard Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Mapping*
Circadian Rhythm / genetics*
Genetic Variation
Genome
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Motor Activity*
Quantitative Trait, Heritable*
Recombination, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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