| Providing the missing link: the exposure science ontology ExO. | |
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MedLine Citation:
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PMID: 22324457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Environmental health information resources lack exposure data required to translate molecular insights, elucidate environmental contributions to diseases, and assess human health and ecological risks. We report development of an Exposure Ontology, ExO, designed to address this information gap by facilitating centralization and integration of exposure data. Major concepts were defined and the ontology drafted and evaluated by a working group of exposure scientists and other ontology and database experts. The resulting major concepts forming the basis for the ontology are "exposure stressor", "exposure receptor", "exposure event", and "exposure outcome". Although design of the first version of ExO focused on human exposure to chemicals, we anticipate expansion by the scientific community to address exposures of human and ecological receptors to the full suite of environmental stressors. Like other widely used ontologies, ExO is intended to link exposure science and diverse environmental health disciplines including toxicology, epidemiology, disease surveillance, and epigenetics. |
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Authors:
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Carolyn J Mattingly; Thomas E McKone; Michael A Callahan; Judith A Blake; Elaine A Cohen Hubal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-12 |
Journal Detail:
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Title: Environmental science & technology Volume: 46 ISSN: 1520-5851 ISO Abbreviation: Environ. Sci. Technol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-20 Completed Date: 2012-09-13 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0213155 Medline TA: Environ Sci Technol Country: United States |
Other Details:
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Languages: eng Pagination: 3046-53 Citation Subset: IM |
Affiliation:
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North Carolina State University, Raleigh, North Carolina 27695, United States. cjmattin@ncsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Environmental Exposure
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analysis* Environmental Health Environmental Pollutants Humans Models, Theoretical* |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES019604/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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