Document Detail

Protracted pneumonitis in young infants associated with perinatally acquired cytomegaloviral infection.
MedLine Citation:
PMID:  180275     Owner:  NLM     Status:  MEDLINE    
Two infants developed a protracted pneumonitis with lower respiratory obstruction beginning at one month of age. Lung biopsy in one suggested a viral etiology which prompted an extensive investigation of each infant for specific etiology. Virologic, serologic, immunologic, and electronmicroscopic studies indicated that cytomegalovirus was a major causative factor. The infections were apparently acquired at birth from infected maternal genital tracts and have persisted for prolonged periods of time. Evidence for gross immunologic defect as a precipitating cause was lacking. These infants serve to emphasize the possible pathologic potential of CMV when acquired in early life even in the absence of iatrogenic immunosuppression.
R J Whitley; D Brasfield; D W Reynolds; S Stagno; R E Tiller; C A Alford
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  89     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes / immunology
Cytomegalovirus Infections / etiology,  immunology,  transmission*
Fetal Diseases / microbiology*
Immunoglobulin A / metabolism
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism
Infant, Newborn
Infant, Newborn, Diseases / etiology*
Pneumonia, Viral / etiology*,  immunology
T-Lymphocytes / immunology
Uterine Cervical Diseases / microbiology
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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