Document Detail

Protozoan cell cycle control.
MedLine Citation:
PMID:  9116796     Owner:  NLM     Status:  MEDLINE    
Many genes belonging to the cyclin-dependent kinase (cdk) family have been isolated from protozoans. While their role in cell cycle has yet to be proven unequivocally, at least one cdk can complement the cdc2ts/cdc28ts mutants in yeasts. Among the interesting questions relating to cdks in protozoa are: whether one cdk acts throughout the whole cell cycle and whether cyclin partnership is absolutely required. In protozoa, cell cycle control is closely associated with developmental control. Many life cycle differentiation phases can only occur during a specific window in the cell cycle. Because of different DNA biosynthetic pathways, some protozoa among the earliest eukaryotic lineages are unresponsive to common inhibitors of DNA synthesis like hydroxyurea. However, many protozoa do have different checkpoint controls in relation to their response to cell cycle inhibitors.
J T Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biological signals     Volume:  5     ISSN:  1016-0922     ISO Abbreviation:  Biol. Signals     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9210083     Medline TA:  Biol Signals     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
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MeSH Terms
Cell Cycle / physiology
Cyclin-Dependent Kinases / physiology
Eukaryota / cytology*,  growth & development,  metabolism
Reg. No./Substance:
EC Kinases

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