Document Detail

Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.
MedLine Citation:
PMID:  19216560     Owner:  NLM     Status:  MEDLINE    
Details of the fungal biosynthetic pathway to helvolic acid and other fusidane antibiotics remain obscure. During product characterization of oxidosqualene cyclases in Aspergillus fumigatus, we found the long-sought cyclase that makes (17Z)-protosta-17(20),24-dien-3beta-ol, the precursor of helvolic acid. We then identified a gene cluster encoding the pathway to helvolic acid, which is controlled by a transcription regulator (LaeA) associated with fungal virulence. Evidence regarding the evolutionary origin and taxonomic distribution of fusidane biosynthesis is also presented.
Silvia Lodeiro; Quanbo Xiong; William K Wilson; Yulia Ivanova; McKenzie L Smith; Gregory S May; Seiichi P T Matsuda
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  11     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-4     Citation Subset:  IM    
Department of Chemistry, Rice University, Houston, Texas 77005, USA.
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MeSH Terms
Anti-Bacterial Agents / chemistry,  isolation & purification*,  pharmacology
Aspergillus fumigatus* / chemistry,  genetics,  metabolism
Fusidic Acid / analogs & derivatives*,  chemistry,  isolation & purification,  pharmacology
Intramolecular Transferases / genetics,  metabolism*
Molecular Structure
Triterpenes / chemistry,  isolation & purification*
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Triterpenes; 0/protosta-13(17),24-dien-3beta-ol; 29400-42-8/helvolic acid; 6990-06-3/Fusidic Acid; EC 5.4.-/Intramolecular Transferases; EC synthase

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