| Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus. | |
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MedLine Citation:
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PMID: 19216560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Details of the fungal biosynthetic pathway to helvolic acid and other fusidane antibiotics remain obscure. During product characterization of oxidosqualene cyclases in Aspergillus fumigatus, we found the long-sought cyclase that makes (17Z)-protosta-17(20),24-dien-3beta-ol, the precursor of helvolic acid. We then identified a gene cluster encoding the pathway to helvolic acid, which is controlled by a transcription regulator (LaeA) associated with fungal virulence. Evidence regarding the evolutionary origin and taxonomic distribution of fusidane biosynthesis is also presented. |
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Authors:
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Silvia Lodeiro; Quanbo Xiong; William K Wilson; Yulia Ivanova; McKenzie L Smith; Gregory S May; Seiichi P T Matsuda |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic letters Volume: 11 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1241-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Rice University, Houston, Texas 77005, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry,
isolation & purification*,
pharmacology Aspergillus fumigatus* / chemistry, genetics, metabolism Fusidic Acid / analogs & derivatives*, chemistry, isolation & purification, pharmacology Intramolecular Transferases / genetics, metabolism* Molecular Structure Stereoisomerism Triterpenes / chemistry, isolation & purification* |
| Grant Support | |
ID/Acronym/Agency:
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5R01AI58045-3/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Triterpenes; 0/protosta-13(17),24-dien-3beta-ol; 29400-42-8/helvolic acid; 6990-06-3/Fusidic Acid; EC 5.4.-/Intramolecular Transferases; EC 5.4.99.7/lanosterol synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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