Document Detail


Protopanaxatriol-type ginsenosides differentially modulate type 1 and type 2 cytokines production from murine splenocytes.
MedLine Citation:
PMID:  15770538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven protopanaxatriol-type ginsenosides and their aglycones including PPT, PT, -Re, -Rg (1), -F (1), -Rh (1), 20(R)-Rh (1) which are closely related in structure were studied for their effects on type 1 and type 2 cytokines production from murine splenocytes and their related mechanisms were examined. The results indicate that PPT, PT and ginsenoside-Re show hardly any or weak effects on concanavalin A (Con A)-induced production of IFN-gamma and IL-4. Ginsenoside-Rh (1) and 20(R)-Rh (1) induce a Con A-induced type 1 cytokine pattern by increasing the production of interleukin-12 (IL-12), the expression of IFN-gamma, T-bet and enhancing NF-kappaB DNA binding activity. In contrast ginsenosides-Rg (1) and -F (1) cause a Con A-induced type 2 cytokines response by increasing the expression of IL-4, GATA-3 and enhancing NF-kappaB DNA binding activity. Thus, these protopanaxatriol-type ginsenosides have different immunomodulatory effects, which might explain the complex immunomodulatory effect of Panax ginseng.
Authors:
Jun-Li Yu; De-Qiang Dou; Xiao-Hong Chen; Hong-Zhen Yang; Na Guo; Gui-Fang Cheng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  71     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-16     Completed Date:  2005-04-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, 1 Xian Nong Tan Street, Xuan Wu District, 100050 Beijing, P. R. China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / drug effects*,  genetics,  metabolism
DNA Primers
DNA-Binding Proteins / drug effects,  metabolism
Dose-Response Relationship, Drug
GATA3 Transcription Factor
Ginsenosides / administration & dosage,  pharmacology,  therapeutic use
Interferon-gamma / drug effects,  metabolism
Interleukin-12 / metabolism
Interleukin-4 / metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
NF-kappa B / drug effects,  metabolism
Panax*
Phytotherapy*
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Sapogenins / administration & dosage,  pharmacology*,  therapeutic use
Spleen / cytology
T-Box Domain Proteins
Trans-Activators / drug effects,  metabolism
Transcription Factors / drug effects,  metabolism
Triterpenes / administration & dosage,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Cytokines; 0/DNA Primers; 0/DNA-Binding Proteins; 0/GATA3 Transcription Factor; 0/Gata3 protein, mouse; 0/Ginsenosides; 0/NF-kappa B; 0/RNA, Messenger; 0/Sapogenins; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; 0/Trans-Activators; 0/Transcription Factors; 0/Triterpenes; 187348-17-0/Interleukin-12; 207137-56-2/Interleukin-4; 34080-08-5/protopanaxatriol; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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