| Protopanaxatriol-type ginsenosides differentially modulate type 1 and type 2 cytokines production from murine splenocytes. | |
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MedLine Citation:
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PMID: 15770538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven protopanaxatriol-type ginsenosides and their aglycones including PPT, PT, -Re, -Rg (1), -F (1), -Rh (1), 20(R)-Rh (1) which are closely related in structure were studied for their effects on type 1 and type 2 cytokines production from murine splenocytes and their related mechanisms were examined. The results indicate that PPT, PT and ginsenoside-Re show hardly any or weak effects on concanavalin A (Con A)-induced production of IFN-gamma and IL-4. Ginsenoside-Rh (1) and 20(R)-Rh (1) induce a Con A-induced type 1 cytokine pattern by increasing the production of interleukin-12 (IL-12), the expression of IFN-gamma, T-bet and enhancing NF-kappaB DNA binding activity. In contrast ginsenosides-Rg (1) and -F (1) cause a Con A-induced type 2 cytokines response by increasing the expression of IL-4, GATA-3 and enhancing NF-kappaB DNA binding activity. Thus, these protopanaxatriol-type ginsenosides have different immunomodulatory effects, which might explain the complex immunomodulatory effect of Panax ginseng. |
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Authors:
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Jun-Li Yu; De-Qiang Dou; Xiao-Hong Chen; Hong-Zhen Yang; Na Guo; Gui-Fang Cheng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Planta medica Volume: 71 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-16 Completed Date: 2005-04-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 202-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, 1 Xian Nong Tan Street, Xuan Wu District, 100050 Beijing, P. R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / drug effects*, genetics, metabolism DNA Primers DNA-Binding Proteins / drug effects, metabolism Dose-Response Relationship, Drug GATA3 Transcription Factor Ginsenosides / administration & dosage, pharmacology, therapeutic use Interferon-gamma / drug effects, metabolism Interleukin-12 / metabolism Interleukin-4 / metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL NF-kappa B / drug effects, metabolism Panax* Phytotherapy* RNA, Messenger / analysis Reverse Transcriptase Polymerase Chain Reaction Sapogenins / administration & dosage, pharmacology*, therapeutic use Spleen / cytology T-Box Domain Proteins Trans-Activators / drug effects, metabolism Transcription Factors / drug effects, metabolism Triterpenes / administration & dosage, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/DNA Primers; 0/DNA-Binding Proteins; 0/GATA3 Transcription Factor; 0/Gata3 protein, mouse; 0/Ginsenosides; 0/NF-kappa B; 0/RNA, Messenger; 0/Sapogenins; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; 0/Trans-Activators; 0/Transcription Factors; 0/Triterpenes; 187348-17-0/Interleukin-12; 207137-56-2/Interleukin-4; 34080-08-5/protopanaxatriol; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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