| Proton spectroscopy of human brain: effects of age and sex. | |
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MedLine Citation:
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PMID: 7824764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS. |
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Authors:
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H C Charles; F Lazeyras; K R Krishnan; O B Boyko; L J Patterson; P M Doraiswamy; W M McDonald |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 18 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-02-16 Completed Date: 1995-02-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 995-1004 Citation Subset: IM |
Affiliation:
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Department of Radiology, Duke University Medical Center, Durham, NC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / metabolism* Aspartic Acid / analogs & derivatives, metabolism Brain / anatomy & histology*, physiology Brain Chemistry / physiology* Choline / metabolism Creatine / metabolism Female Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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