Document Detail


Proton spectroscopic imaging at 4.1 tesla in patients with malformations of cortical development and epilepsy.
MedLine Citation:
PMID:  9109893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used proton magnetic resonance spectroscopic imaging (MRSI) at 4.1 tesla in patients with malformations of cortical development (MCDs) and epilepsy. We compared the spectroscopic results with normative data using 2 SDs (95% confidence) above normal values for detection of significant abnormalities for creatine-N-acetylated compounds (Cr/NA) ratio and choline-N-acetylated compounds (Cho/NA). The results were correlated with clinical, EEG, and histologic findings. Patients with focal cortical dysplasia showed significant metabolic abnormalities in correspondence with the structural lesions, whereas patients with heterotopia and polymicrogyria demonstrated no subcortical MRSI abnormalities. Significant correlations were found between the metabolic abnormalities and the frequency of seizures but not with the degree of interictal EEG discharges. Quantitative neuronal and glial cell counts revealed no statistically significant correlation between cell loss and the abnormal metabolic ratios in those who underwent surgery. These preliminary findings suggest that MRSI-based metabolic abnormalities in patients with MCDs are variable and are likely to be associated with complex cellular mechanisms involving the regulation of NA, total Cr content, and Cho.
Authors:
R Kuzniecky; H Hetherington; J Pan; J Hugg; C Palmer; F Gilliam; E Faught; R Morawetz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  48     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1018-24     Citation Subset:  AIM; IM    
Affiliation:
UAB Epilepsy Center, University of Alabama at Birmingham 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Adolescent
Adult
Brain / abnormalities,  metabolism
Brain Neoplasms / diagnosis
Cerebral Cortex / abnormalities*,  pathology*
Choline / metabolism
Choristoma / diagnosis
Creatine / metabolism
Electroencephalography
Epilepsy / diagnosis*
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy*
Male
Middle Aged
Protons
Reference Values
Grant Support
ID/Acronym/Agency:
R01NS-33919/NS/NINDS NIH HHS; R01NS-33991/NS/NINDS NIH HHS; RR-07723/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Protons; 57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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