Document Detail

Proton pump inhibitors reduce gallbladder function.
MedLine Citation:
PMID:  16858534     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the authors' previous study of gallbladder function before and after fundoplication, 58% of the patients demonstrated preoperative gallbladder motor dysfunction, and 86% of those retested after operation and cessation of proton pump inhibitors (PPIs) normalized. Because no study has directly assessed the impact of antisecretory agents on gallbladder function, this study measured gallbladder ejection fraction (GBEF) in healthy volunteers before and after initiation of PPIs. METHODS: A total of 19 subjects completed the study, which included baseline determination of GBEF by cholecystokinin-stimulated hepatobiliary acid scan, 30 days of antisecretory therapy with omeprazole (40 mg daily), and repeat GBEF on day 30. Subjects were surveyed regarding compliance and symptoms. RESULTS: For 15 of 19 subjects, PPI therapy was associated with reduced gallbladder motility. Evolution of symptoms consistent with a biliary etiology was reported by 26.7% of these subjects. CONCLUSIONS: Short-term PPI therapy reduces gallbladder motility in healthy volunteers. Chronic PPI therapy may pose a risk for long-term gallbladder dysfunction and biliary complications.
M A Cahan; L Balduf; K Colton; B Palacioz; W McCartney; T M Farrell
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Publication Detail:
Type:  Journal Article     Date:  2006-07-20
Journal Detail:
Title:  Surgical endoscopy     Volume:  20     ISSN:  1432-2218     ISO Abbreviation:  Surg Endosc     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1364-7     Citation Subset:  IM    
Department of Surgery, University of North Carolina at Chapel Hill, Campus Box 7081, Chapel Hill, North Carolina 27599-7081, USA.
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MeSH Terms
Enzyme Inhibitors / adverse effects,  pharmacology*
Gallbladder / drug effects*,  physiology*
Gastrointestinal Diseases / chemically induced
Movement / drug effects
Omeprazole / adverse effects,  pharmacology*
Proton Pumps / antagonists & inhibitors*
Reference Values
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Proton Pumps; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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