Document Detail

Proton pump inhibitors and hypomagnesemia: a rare but serious complication.
MedLine Citation:
PMID:  23538697     Owner:  NLM     Status:  In-Data-Review    
Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg(2+) absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center. They found that patients taking PPIs, compared with those receiving histamine-2 antagonists or no acid-suppressive medications, had a decline in serum Mg(2+) after adjusting for several clinical and laboratory factors. The effect was seen only in those concomitantly receiving diuretics.
Mark A Perazella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  83     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  553-6     Citation Subset:  IM    
Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
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