| Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts. | |
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MedLine Citation:
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PMID: 18384663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic oesophageal inflammation and related oxidative stress are important in the pathogenesis of erosive oesophagitis (EO) and its malignant progression. AIM: To study the effect of proton pump inhibitors (PPIs) on oesophageal cellular immune response and oxidative damage in EO patients. METHODS: Forty gastro-oesophageal reflux disease (GERD) patients [non-erosive reflux disease (NERD): 15, EO: 25] were included, after 7 days off antisuppressive drugs. EO patients were randomized to 20-mg rabeprazole once daily for either 4 or 8 weeks with baseline and follow-up endoscopy with distal oesophageal biopsies. T lymphocytes, macrophages and mast cells were quantified by immunohistochemistry. DNA adducts were measured by analysis of 8-oxo-deoxyguanosine levels. RESULTS: Erosive oesophagitis patients had more T lymphocytes and CD8(+) T lymphocytes in squamous epithelium than NERD patients (P = 0.001, P = 0.002, respectively). Levels of DNA adducts between both groups were, however, not different (P = 0.99). Four- and eight-week rabeprazole treatment in EO patients resulted in a significant decrease in number of T lymphocytes and CD8(+) T lymphocytes (all P < 0.05). PPIs did not, however, affect levels of DNA adducts. CONCLUSIONS: Short-term PPI therapy in EO patients reduces the oesophageal cellular immune response, but does not change oxidative damage. PPI therapy may therefore not be effective in reducing the risk of oesophageal cancer in GERD patients. |
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Authors:
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P J F De Jonge; P D Siersema; S G J Van Breda; K P M Van Zoest; D J Bac; I Leeuwenburgh; R J Th Ouwendijk; H Van Dekken; J G Kusters; E J Kuipers |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-03-31 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 28 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-05 Completed Date: 2008-12-10 Revised Date: 2009-01-24 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 127-36 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands. p.dejonge@erasmusmc.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / immunology Antigens, Differentiation, Myelomonocytic / immunology Barrett Esophagus / immunology DNA Adducts / drug effects*, metabolism Female Gastroesophageal Reflux / drug therapy, immunology* Humans Immunity, Cellular Male Mast Cells / immunology Middle Aged Oxidative Stress / genetics, immunology Proton Pump Inhibitors / therapeutic use* T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/DNA Adducts; 0/Proton Pump Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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