| Proton pump inhibitor therapy associated with lower glycosylated hemoglobin levels in type 2 diabetes. | |
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MedLine Citation:
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PMID: 22218624 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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METHODS: Electronic medical records in a family medicine residency program office practice were reviewed for 73 individuals with type 2 diabetes (not taking insulin), for whom PPIs were prescribed. Values for glycosylated hemoglobin (HbA1c) for periods of time when a PPI had been prescribed were compared with HbA1c levels for periods of time with no record of PPI prescribing or over-the-counter PPI use. RESULTS: The mean HbA1c for patients not taking insulin was 7.11 during periods with recorded prescribing or over-the-counter use of PPIs, compared with 7.70 during periods without recorded PPI therapy (P = .001). Mean HbA1c for metformin monotherapy was not significantly different (6.81 with PPI vs. 7.10 without PPI; n = 16; P = .25). Mean HbA1c was significantly different for combination therapy that included metformin and/or sulfonylurea and/or giltazone (7.26 vs. 7.80; n = 27; P = .002). CONCLUSION: The observed association between PPI therapy and lower HbA1c levels suggests that PPIs may be useful as adjunctive therapy for type 2 diabetes. |
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Authors:
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Michael A Crouch; Ivan N Mefford; Ekpedeme U Wade |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Board of Family Medicine : JABFM Volume: 25 ISSN: 1557-2625 ISO Abbreviation: J Am Board Fam Med Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256526 Medline TA: J Am Board Fam Med Country: United States |
Other Details:
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Languages: eng Pagination: 50-4 Citation Subset: IM |
Affiliation:
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the Memorial Family Medicine Residency Program, Sugar Land, Texas; and Fort Bend Premier Care, Richmond, Texas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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