| Proton magnetization transfer effect in rat liver lactate. | |
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MedLine Citation:
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PMID: 11979566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Off-resonance lactate magnetization transfer (MT) experiments were performed on the in situ rat liver under perfused and ischemic conditions. A significant MT effect for lactate methyl protons was observed. The effect was larger for the ischemic condition than for the perfused condition, and was largest in the blood-filled ischemic livers. The size of the motionally restricted lactate pool, determined using a two-pool model fit, was estimated to be about 1% in perfused livers and about 1.8-2.5% after more than 1 hr of onset of ischemia, suggesting that lactate in liver is almost fully NMR-visible. The MT data for both the perfused and the ischemic condition appeared to be better approximated when assuming a superLorentzian lineshape for the immobile pool rather than a Gaussian lineshape. Finally, the experiments demonstrated a coupling between the lactate methyl and water protons, which may be mediated by macromolecules. |
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Authors:
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Tom Dresselaers; Niki Bergans; Paul Van Hecke; Florent Vanstapel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 47 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-23 Completed Date: 2002-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 880-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Biomedische NMR-Eenheid, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ischemia Lactates / analysis* Liver / anatomy & histology, blood supply, chemistry* Magnetic Resonance Imaging / methods* Male Rats Rats, Wistar Water |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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