Document Detail


Proton magnetic resonance spectroscopy of small regions (1 mL) localized inside superficial human tumors. A clinical feasibility study.
MedLine Citation:
PMID:  1963074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is demonstrated that the stimulated echo technique for proton magnetic resonance spectroscopy (MRS) can be used to study metabolites in volumes of interest (VOIs) as small as 1 mL localized within superficial human tumors. Access to these small VOIs is important for characterization of tissue regions within a tumor, before, during and after treatment. Spectral appearance resembles that from studies on extracts, and cell suspensions and perfused cells of several tumor types. For the first time proton MRS was used to study cancer treatment in vivo in humans, for a case of radiation treatment of squamous cell carcinoma. No spectral evidence of changed metabolism prior to reduction in tumor size was found. However, after the first period of radiation (39 Gy, 4 weeks), complete disappearance of the metabolite resonances from the spectrum was observed, while a considerable mass still remained, suggesting effective cell destruction upon treatment. Needle aspiration cytology of this mass showed absence of malignant cells, supporting this result.
Authors:
P C van Zijl; C T Moonen; J Gillen; P F Daly; L S Miketic; J A Frank; T F DeLaney; O Kaplan; J S Cohen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  NMR in biomedicine     Volume:  3     ISSN:  0952-3480     ISO Abbreviation:  NMR Biomed     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Affiliation:
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / chemistry*,  radiotherapy,  secondary
Feasibility Studies
Head and Neck Neoplasms / chemistry*,  radiotherapy,  secondary
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy / methods
Male
Middle Aged
Protons
Chemical
Reg. No./Substance:
0/Protons

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