| Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patients. | |
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MedLine Citation:
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PMID: 17208418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous neuroimaging studies have suggested that obsessive-compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N-acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n=7), responders to SSRI with an atypical antipsychotic (group B: n=8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n=5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate. |
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Authors:
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Satsuki Sumitani; Masafumi Harada; Hitoshi Kubo; Tetsuro Ohmori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-06 |
Journal Detail:
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Title: Psychiatry research Volume: 154 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-04-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 85-92 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, 18-15 Kuramoto-cho 3, Tokushima 770-8503, Japan. satsuki@clin.med.tokushima-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use Aspartic Acid / analogs & derivatives*, metabolism Basal Ganglia / drug effects, physiopathology Benzodiazepines / therapeutic use Dominance, Cerebral / physiology Dose-Response Relationship, Drug Drug Therapy, Combination Energy Metabolism / drug effects, physiology* Female Fluvoxamine / therapeutic use Frontal Lobe / drug effects, physiopathology Gyrus Cinguli / drug effects, physiopathology* Humans Magnetic Resonance Spectroscopy* Male Middle Aged Nerve Net / drug effects, physiopathology Obsessive-Compulsive Disorder / diagnosis, drug therapy, physiopathology* Paroxetine / therapeutic use Prefrontal Cortex / drug effects, physiopathology Risperidone / therapeutic use Serotonin Uptake Inhibitors / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Serotonin Uptake Inhibitors; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 54739-18-3/Fluvoxamine; 56-84-8/Aspartic Acid; 61869-08-7/Paroxetine; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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