Document Detail

Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patients.
MedLine Citation:
PMID:  17208418     Owner:  NLM     Status:  MEDLINE    
Numerous neuroimaging studies have suggested that obsessive-compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N-acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n=7), responders to SSRI with an atypical antipsychotic (group B: n=8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n=5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate.
Satsuki Sumitani; Masafumi Harada; Hitoshi Kubo; Tetsuro Ohmori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Psychiatry research     Volume:  154     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Psychiatry, Institute of Health Biosciences, University of Tokushima Graduate School, 18-15 Kuramoto-cho 3, Tokushima 770-8503, Japan.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Aspartic Acid / analogs & derivatives*,  metabolism
Basal Ganglia / drug effects,  physiopathology
Benzodiazepines / therapeutic use
Dominance, Cerebral / physiology
Dose-Response Relationship, Drug
Drug Therapy, Combination
Energy Metabolism / drug effects,  physiology*
Fluvoxamine / therapeutic use
Frontal Lobe / drug effects,  physiopathology
Gyrus Cinguli / drug effects,  physiopathology*
Magnetic Resonance Spectroscopy*
Middle Aged
Nerve Net / drug effects,  physiopathology
Obsessive-Compulsive Disorder / diagnosis,  drug therapy,  physiopathology*
Paroxetine / therapeutic use
Prefrontal Cortex / drug effects,  physiopathology
Risperidone / therapeutic use
Serotonin Uptake Inhibitors / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 0/Serotonin Uptake Inhibitors; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 54739-18-3/Fluvoxamine; 56-84-8/Aspartic Acid; 61869-08-7/Paroxetine; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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